Anti-D immunoglobulin is used to prevent formation of antibodies during pregnancy when a mother has Rh-negative blood and the baby is Rh-positive. It may also be given after a person with Rh-negative blood receives a transfusion with Rh-positive blood.
It is also used to treat immune thrombocytopenia (a blood disorder wherein there is very low platelet counts). Platelets help to clot blood.
Anti-D immunoglobulin injection is to be given intravenously into the vein. It is delivered directly into the bloodstream via the blood vessel.
Your doctor or nurse will administer the injection for you.
Do not use Anti-D immunoglobulin if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to human immunoglobulin products.
Alert your doctor if you have the following conditions:
- severe blood disorders
- immunoglobulin A deficiency
- Rh(D) positive (when used to prevent antibody formation)
- Rh(D) negative previously sensitised to the Rh(D) antigen or have had your spleen removed (when used to treat ITP)
as Anti-D immunoglobulin may not be suitable for you.
Inform your doctor if you have bleeding disorders.
Let your doctor know if you are breastfeeding.
Inform your doctor if you have been recently vaccinated. Do not receive any vaccinations without first asking your doctor.
Your doctor may need to perform blood tests to check your response to this medicine.
Anti-D immunoglobulin may cause any of the following side effects: headache, dizziness, weakness, paleness, diarrhoea, nausea, vomiting, muscle or joint pain, rash, sweating and pain, redness, warmth and swelling at injection site.
If you develop rashes, breathlessness, swollen mouth or eyes, stop using Anti-D immunoglobulin and inform your doctor quickly. These could be signs of an allergic reaction.
When given for the treatment of idiopathic thrombocytopenic purpura, Anti-D immunoglobulin may cause some side effects that may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- back pain, chills, dark urine, shortness of breath or swelling of the hand or feet
- unusual bleeding or bruising
- unusual weakness or tiredness
- unable to pass urine or decreased frequency of urination
- troubled breathing
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not use Anti-D immunoglobulin with live attenuated vaccines (e.g. measles, mumps, rubella or varicella) during treatment and within 3 months after treatment with Anti-D immunoglobulin.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Avoid alcohol.
Store in the refrigerator, between 2-8 °C. Do not allow to freeze. If frozen, anti-D immunoglobulin will become ineffective and should not be used.
Protect from light.
Medicines must not be used past the expiry date.
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